A generalized robust allele‐based genetic association test
نویسندگان
چکیده
منابع مشابه
A powerful and robust test in genetic association studies.
There are several well-known single SNP tests presented in the literature for detecting gene-disease association signals. Having in place an efficient and robust testing process across all genetic models would allow a more comprehensive approach to analysis. Although some studies have shown that it is possible to construct such a test when the variants are common and the genetic model satisfies...
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Motivation Second generation sequencing technologies are being increasingly used for genetic association studies, where the main research interest is to identify sets of genetic variants that contribute to various phenotypes. The phenotype can be univariate disease status, multivariate responses and even high-dimensional outcomes. Considering the genotype and phenotype as two complex objects, t...
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ژورنال
عنوان ژورنال: Biometrics
سال: 2021
ISSN: 0006-341X,1541-0420
DOI: 10.1111/biom.13456